Genetic Engineering and Diseases – Gene Drive & Malaria

  • Published: 21 September 2016
  • We have the choice to attack one of our oldest enemies with genetic engineering. But should we do it?

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    Big thanks to James Gurney and Roya Haghighat-Khah for their help and advice with this video!


    Lucien Delbert, Mike C, Ricardo Chavarria, Juha Wellman, Zachary Jordan, Patrick Chang, Adrian Mihali, Nicodemos Nicodemou, Lacey Larson, Austin Earnest, Andre Wee, Koroslak, Alex Brady, Roberto Cano, Andreas Stokholm, Plamen Ivanov, E Smith, Kieran Hunter-East, Christopher Trinh, Tony Kwok, Adam Rabenstein, Andrew Whitehurst, Alena Vlachova, Mackenzie Broadbent, Andreas Hertle, Martin Petersen, Kasturi Raghavan, Gregory Griffin, KiaTheDead, Aaron Stevens, Jimmy C, Benedikt Jaletzke, Jonathan Bowler, Zdravko Šašek, Wouter Stokhof, Zealotus, Long Vu, Fatman13, Jeremy Dumet, Miles Spoor, Mirton I, Al Fl, Jonathan Carter, Stanislaw Wasowicz, Marek Turcani, Francisco Santos, Justin Choi, Dagoberto Chapa, Chip Salzenberg, TinFung, Bob Bergeron, Peer, Justin Elstrott, Rachid Malik, Octavio Astillo, Romain Isnel, Rich Sekmistrz, Kuosora, Mozart Petter, Justin Jeffries, Nicola Licheri, Bahram Malaekeh, Florent Petterschmitt, David Mark, Gaby Germanos, Shweta Bharadwai, Lux Stamm, Marc Johann, Joe, Nefaur Khandker, Anders Madsen, Sarah Yoshi, monoxide, Brandon Meador, Dovydas Bartkevicius, Tyler Vigen, Michael Niella, Gordon Timilty, Slava Dzyba, Bagel Krippen Chandra, KodinCage, Miikka Harjuntausta, Magid Elgady, Vince Houmes, Irae Carvalho, Josh Talbot, Mr.Z, Pawel Urbanek, Russ Clarke, Lucas Tostes, Oscar Chamaria, Zachary Langdon, Steve Bollenbaugh, Xiaogiang Zheng, Peter LoPinto, Jenny Nordenborg, Evan Faas, Greg Fowler, Cicmil Mladen, Canut Durgun, Malovich, Cedric, Dave Anderson, Jones, Elliot, Denis Dube, David Allen, Dawson Reid, Jake Zwirdowski, Denis Leu


    Harvard FAQs on gene drive:

    Research paper on using CRISPR for malaria gene drive:

    Nature article on engineered mosquitos:

    STAT new article on using gene drive against Zika:

    Tech review article on using gene drive against malaria:

    Smithsonian on deadliness of mosquitos:

    Science article about the risks of the technology:

    New Yorker on Pros and Cons:

    Gates note on death rate through mosquitos:

    Status quo on field trial in the U.S.:

    Evolution working against gene drive technology:

    Research paper on evolution of resistance against gene drive:

    Science news on possible safety feature for gene drive:

    Help us caption & translate this video!

Comments • 18 315

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    • Alexandra Santos
      Alexandra Santos  4 days back


      Me: KAMIKAZI *planes crash into the merch*

    • Austin Smith
      Austin Smith  4 weeks back

      I think this debate may be one of the great filters discussed in another video. Either we're supposed to genetically engineer disease carrying creatures to be immune in order to progress as a dominant race, or it backfires against us and wipes us out. This is one of the filters.

    • Rejjaqul Hasnat
      Rejjaqul Hasnat  1 months back

      What if plasmodium develops resistance against the antibodies?

    • Maxi Immortality
      Maxi Immortality  3 months back


    • Polly Huang
      Polly Huang  4 months back

      Do it mofo

  • Pro Blocks
    Pro Blocks  42 minutes back

    Do it

    • Pen G
      Pen G  14 hours back

      Those enginerd mosquitos will get bullied for when mosquitoes almost get extinct.

      • DarK_Snake Venom
        DarK_Snake Venom  1 days back

        “Project needlenose”


        • Crazy Cousin
          Crazy Cousin  2 days back

          Guy: we have technology to change an entire species
          Humans: already killed 35+ species

          • Crazy Cousin
            Crazy Cousin  2 days back

            Umm mosquitos love my cold blood
            So that’s why at night
            I go lockdown
            Like literary
            I lock all doors

            • Brenden Castillo
              Brenden Castillo  2 days back

              Kill malaria forever

              • Taquito_con_ Queso
                Taquito_con_ Queso  2 days back

                We should ask Tierzoo to be sure this isnt going to change the game

                • Solviet Union
                  Solviet Union  3 days back

                  *RELEASE THE PHAGES*

                  • Cheeseburger Monkey
                    Cheeseburger Monkey  3 days back

                    student: teehee
                    teacher: wat so funny
                    student: nothing
                    brain: *elon muskeeto*

                    • Charlotte Holmes
                      Charlotte Holmes  4 days back

                      Hey bois initiate cut blood stream.

                    • Menos The Name
                      Menos The Name  4 days back

                      I'd like to know if the gene change will be dominant for all generations or just a few.
                      Sure, this can save a lot of people, and it might wipe out all mosquitoes, so the majority of earth will be messed up.

                      • Menos The Name
                        Menos The Name  9 hours back

                        If you say so, fellow jokeass = )

                        If you're interested about the video content and the research it includes I could just copy paste what I wrote. 👍

                      • David Davesby
                        David Davesby  12 hours back

                        @Menos The Name nope cannot see it, might be for the best jockass!!

                      • Menos The Name
                        Menos The Name  18 hours back

                        @David Davesby Can't you see it?
                        I edited it a bit, but I can see my comment above your 'Think ya deleted'

                        Any happiness you feel is a plus for me ^^
                        I'll make sure to start whatevering in video form d c" )

                      • David Davesby
                        David Davesby  18 hours back

                        Think ya deleted your comment started with HiHi Will do poor fellow!... I'm eager to hear you speak, I love laughing at people

                    • abde ba
                      abde ba  4 days back

                      why not kill the mosquitos, less dangerous and no body's goin to miss them, i bet the people profiting from selling medicine will never let that happen.

                      • YTWendyEL
                        YTWendyEL  4 days back

                        Well we don't really mess up so why not?

                        • io Games
                          io Games  4 days back

                          Unleash the bacteriophages!!!!

                          • Kimleng Suon
                            Kimleng Suon  5 days back


                            • Kimleng Suon
                              Kimleng Suon  5 days back

                              Many people in Cambodia are infected

                              • earth you are here
                                earth you are here  5 days back

                                malaria is like strings opening

                                • kumkum jain
                                  kumkum jain  5 days back

                                  pl do mention tht there r 5 types of malaria already. as also dengue, chikanguniya

                                  • Vance Biondo
                                    Vance Biondo  5 days back

                                    That's AMAZING! LOL

                                    • Vance Biondo
                                      Vance Biondo  5 days back

                                      I'd just remind you .. PARISITES.. CQNT BE SEEN.👌😁🖐 how ya doing?

                                      • Conteúdo Original
                                        Conteúdo Original  5 days back

                                        Everybody will die, so it's best at least try, because, well, very body will die, so it's best at least make it slower. I'm confused but in my head it makes much more sense.

                                        • bombæ
                                          bombæ  5 days back

                                          Me : *sees this video*
                                          Also me : *puts on bee worker outfit* You cannot kill me malaria.

                                          • Ura Elvins
                                            Ura Elvins  6 days back

                                            I generally think that using this kind of technology could be a dawn of new era for medicine and if tested under very strict conditions could/will work and that gives us the chance to win the fight over marlaria. Even though on the other hand people debating that editing natural could be dangerous and could lead to genetic mutations which using "science" cause cancer. But if they find a way around this problem and the 50/50 chance of passing the gene down the line this would work and that us and the people which make this possible need to wake up and smell what's cooking.the death if thousand of young kids and world lead need to get together and help fund this fight!

                                            • sneaky boi
                                              sneaky boi  6 days back

                                              20 people died when I was eating my borito

                                              • Boss sentient Hunhow
                                                Boss sentient Hunhow  7 days back

                                                Malaria: You can't eradicate us!
                                                Gene scientists: Hold my musquito...

                                                • Unofficial CallMeCarson Advertiser

                                                  I hope it will happen in a good way
                                                  And some people are right, it's needs to be tested millions and millions times

                                                  • Juuzou Suzuya
                                                    Juuzou Suzuya  1 weeks back


                                                    • Suneil Parimoo
                                                      Suneil Parimoo  1 weeks back

                                                      "killing someone from the inside and then taking their skin as camouflage" malaria is microbial Hannibal?

                                                      • Jon S
                                                        Jon S  1 weeks back

                                                        Do it!

                                                        • Shayan Chougule
                                                          Shayan Chougule  1 weeks back

                                                          Use it

                                                          • LoveYourselfBTS Answer In ROBLOX

                                                            you know what is more brutal?

                                                            they are smiling while killing

                                                            • Aaron Marks
                                                              Aaron Marks  1 weeks back

                                                              Sounds like the lead-up to an unintended apocalypse

                                                              • Alto Paringitermsultimate

                                                                If my cells carry some IDC things just get out of our body im surely it is an insane thing XD

                                                                • The only thing The
                                                                  The only thing The  1 weeks back

                                                                  I thought plague was dead

                                                                  • Always Chill
                                                                    Always Chill  1 weeks back

                                                                    i say we should use it

                                                                    • OAM_Delta G
                                                                      OAM_Delta G  1 weeks back

                                                                      CRISPR needs to be used. Malaria will not disappear by itself. The only way to make a species exctinct is with a drastic change and CRISPR will make that drastic change. Like if you want to use CRISPR!

                                                                      • Sam Williams
                                                                        Sam Williams  1 weeks back

                                                                        idiot, we cant use it willy nilly.
                                                                        the Eco system is very fragile and we humans are dumb.
                                                                        the consequences could be deadly for all of us.
                                                                        stop begging for likes btw, its pathetic.

                                                                    • Alexandra Santos
                                                                      Alexandra Santos  1 weeks back

                                                                      We should use it... its been 7 years since we found genetic engineering

                                                                      • Actionbastard
                                                                        Actionbastard  1 weeks back

                                                                        Neat. Save lives in a shit hole country so they can overbreed and then come and ruin ours. In the end it was the people there who were the disgusting plague waiting to happen and not the bugs. They were the cure.

                                                                        • Atlas
                                                                          Atlas  5 days back

                                                                          Bit racist innit

                                                                      • Terraformed Mars Runaway

                                                                        Tarallia/more deadly than marina

                                                                        • MeiMein_OW
                                                                          MeiMein_OW  2 weeks back

                                                                          Why don’t we make humans resistant to it?

                                                                          • Rynecade Contreras
                                                                            Rynecade Contreras  2 weeks back

                                                                            Just pressed F today some respect on the kids that died

                                                                            • Quick Science
                                                                              Quick Science  2 weeks back


                                                                              • maria thereza costa
                                                                                maria thereza costa  2 weeks back

                                                                                use it man

                                                                                • XeanderMan
                                                                                  XeanderMan  2 weeks back

                                                                                  In my opinion, we should really use it

                                                                                  • Rainkow Reit
                                                                                    Rainkow Reit  2 weeks back


                                                                                    • Mulatto Air
                                                                                      Mulatto Air  2 weeks back

                                                                                      Can CRISPER be used to modify bugs to eat primarily mosqitoes or create a bug that only eats mosqitoes and their eggs? Hopefully deminishing the population greatly and eventually leading to their extinction

                                                                                      • stamatis tsikrikis
                                                                                        stamatis tsikrikis  2 weeks back

                                                                                        I believe that we should do it but malaria will adapt fast (my personal opinion)